A case of an intravascular hemolysis after multiple aortic and mitral valves replacement is described. Hemolysis was observed after second and third operation of mitral valve prosthesis due to prosthesis dysfunction -- paravalvular leak. We discuss the possibilities of treatment, difficulties in decision making in a patient who is in good condition but hemolysis is clinically significant, not amenable to conventional treatment and there is an increased risk of another operation.