Post-mortem human brain autoradiography of the norepinephrine transporter using (S,S)-[18F]FMeNER-D2

Eur Neuropsychopharmacol. 2005 Oct;15(5):517-20. doi: 10.1016/j.euroneuro.2005.01.007. Epub 2005 Apr 7.

Abstract

The binding of the norepinephrine transporter radioligand, (S,S)-[18F]FMeNER-D2, to human brain post-mortem was examined in vitro by whole hemisphere autoradiography. The rank order for the density of labelling was: locus coeruleus>>cortex approximately cerebellum approximately thalamus>caudate approximately putamen. The NET-selectivity of binding was confirmed by co-incubation with desipramine. The dual NET/SERT inhibitor duloxetine also inhibited specific binding, whereas PE2I or citalopram had no evident effect.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenergic Uptake Inhibitors / pharmacology
  • Autopsy
  • Autoradiography
  • Brain / metabolism*
  • Brain / pathology
  • Desipramine / pharmacology
  • Duloxetine Hydrochloride
  • Fluorine Radioisotopes / pharmacokinetics
  • Humans
  • Morpholines / pharmacokinetics*
  • Postmortem Changes
  • Radioligand Assay
  • Thiophenes / pharmacology

Substances

  • 2-(alpha-(2-fluoromethoxyphenoxy)benzyl)morpholine
  • Adrenergic Uptake Inhibitors
  • Fluorine Radioisotopes
  • Morpholines
  • Thiophenes
  • Duloxetine Hydrochloride
  • Desipramine