Recurrence of myomas after myomectomy in women pretreated with leuprolide acetate depot or placebo

Fertil Steril. 1992 Jul;58(1):205-8. doi: 10.1016/s0015-0282(16)55164-4.

Abstract

The recurrence of myomas and myoma-related symptoms was evaluated in women participating in a randomized, double-blind, P-controlled study of the efficacy of LA depot before myomectomy. After 27 to 38 months of follow-up, the recurrence of myomas was found to be greater when at least four myomas were resected. Myoma recurrence was not associated with pretreatment or preoperative uterine volume, resected myoma mass, or preoperative medical therapy.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Combined Modality Therapy
  • Delayed-Action Preparations
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Leuprolide / administration & dosage
  • Leuprolide / therapeutic use*
  • Myoma / drug therapy
  • Myoma / epidemiology*
  • Myoma / surgery*
  • Recurrence
  • Uterine Neoplasms / drug therapy*
  • Uterine Neoplasms / epidemiology*
  • Uterine Neoplasms / surgery

Substances

  • Delayed-Action Preparations
  • Leuprolide