Abstract
cMG1 is a primary response gene first identified in a rat intestinal epithelial (RIE-1) cell-line [(1990) Oncogene 5, 1081-1083]. A number of mitogens, including epidermal growth factor (EGF), angiotensin II (AII), serum and insulin rapidly induced 2- to 6-fold increases of cMG1 mRNA in RIE-1 cells, while transforming growth factor-beta caused a small reduction. Cyclic AMP-elevating agents blocked the increase of cMG1 mRNA induced by EGF. The AII-stimulated increase of cMG1 mRNA was blocked by the depletion of protein kinase C, whereas the EGF-stimulated increase was not affected, indicating that protein kinase C-dependent and -independent signalling pathways stimulate cMG1 expression.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3T3 Cells
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Angiotensin II / pharmacology
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Animals
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Blotting, Northern
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Butyrate Response Factor 1
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Cell Line
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DNA-Binding Proteins*
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Epidermal Growth Factor / pharmacology
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Epithelial Cells
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Epithelium / metabolism
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Gene Expression Regulation / drug effects*
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Genes, fos
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Immediate-Early Proteins*
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Insulin / pharmacology
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Intestinal Mucosa / metabolism*
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Intestines / cytology
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Mice
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Mitogens / pharmacology*
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Protein Kinase C / metabolism
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Proteins / genetics*
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RNA, Messenger / metabolism
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Rats
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Signal Transduction
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Tristetraprolin
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Tumor Cells, Cultured
Substances
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Butyrate Response Factor 1
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DNA-Binding Proteins
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Immediate-Early Proteins
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Insulin
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Mitogens
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Proteins
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RNA, Messenger
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Tristetraprolin
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Zfp36 protein, mouse
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Zfp36 protein, rat
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Zfp36l1 protein, rat
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Angiotensin II
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Epidermal Growth Factor
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Protein Kinase C