Phosphorylation of CARMA1: the link(er) to NF-kappaB activation

Daniel Rueda; Margot Thome

doi:10.1016/j.immuni.2005.11.007

Phosphorylation of CARMA1: the link(er) to NF-kappaB activation

Immunity. 2005 Dec;23(6):551-3. doi: 10.1016/j.immuni.2005.11.007.

Authors

Daniel Rueda¹, Margot Thome

Affiliation

¹ Department of Biochemistry, University of Lausanne, BIL Biomedical Research Center, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland.

PMID: 16356853
DOI: 10.1016/j.immuni.2005.11.007

Abstract

Antigen receptor-induced NF-kappaB activation depends on receptor-proximal and -distal signaling events. Two papers in this issue of Immunity demonstrate that PKC-dependent phosphorylation of CARMA1 is the critical molecular link that controls the activation of the IKK signalosome and NF-kappaB.

Publication types

Comment

MeSH terms

Animals
Apoptosis Regulatory Proteins / metabolism*
CARD Signaling Adaptor Proteins
Guanylate Kinases / metabolism*
Immunity, Cellular / physiology*
NF-kappa B / metabolism*
Phosphorylation
Protein Kinase C / metabolism
Receptors, Antigen / metabolism
Signal Transduction / immunology*
Transcriptional Activation / immunology*

Substances

Apoptosis Regulatory Proteins
CARD Signaling Adaptor Proteins
Card11 protein, mouse
NF-kappa B
Receptors, Antigen
Protein Kinase C
Guanylate Kinases