SH3--an abundant protein domain in search of a function

FEBS Lett. 1992 Jul 27;307(1):55-61. doi: 10.1016/0014-5793(92)80901-r.

Abstract

Src-homology 3 is a small protein domain of about 60 amino acid residues. It is probably made of beta-sheets. SH3 is present in a large number of eukaryotic proteins which are involved in signal transduction, cell polarization and membrane-cytoskeleton interactions. Here we review its occurrence and discuss possible functions of this domain.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • CSK Tyrosine-Protein Kinase
  • Molecular Sequence Data
  • Peptide Fragments / physiology*
  • Protein-Tyrosine Kinases / chemistry*
  • Saccharomyces cerevisiae / chemistry
  • Sequence Alignment
  • Signal Transduction / physiology
  • src-Family Kinases

Substances

  • Peptide Fragments
  • Protein-Tyrosine Kinases
  • CSK Tyrosine-Protein Kinase
  • src-Family Kinases