Abstract
Src-homology 3 is a small protein domain of about 60 amino acid residues. It is probably made of beta-sheets. SH3 is present in a large number of eukaryotic proteins which are involved in signal transduction, cell polarization and membrane-cytoskeleton interactions. Here we review its occurrence and discuss possible functions of this domain.
MeSH terms
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Amino Acid Sequence
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CSK Tyrosine-Protein Kinase
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Molecular Sequence Data
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Peptide Fragments / physiology*
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Protein-Tyrosine Kinases / chemistry*
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Saccharomyces cerevisiae / chemistry
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Sequence Alignment
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Signal Transduction / physiology
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src-Family Kinases
Substances
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Peptide Fragments
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Protein-Tyrosine Kinases
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CSK Tyrosine-Protein Kinase
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src-Family Kinases