Application of UL144 molecular typing to determine epidemiology of cytomegalovirus infections in preterm infants

R Stranska; R Schuurman; M Toet; M Verboon-Maciolek; L S de Vries; A M van Loon

doi:10.1128/JCM.44.3.1108-1110.2006

Application of UL144 molecular typing to determine epidemiology of cytomegalovirus infections in preterm infants

J Clin Microbiol. 2006 Mar;44(3):1108-10. doi: 10.1128/JCM.44.3.1108-1110.2006.

Authors

R Stranska¹, R Schuurman, M Toet, M Verboon-Maciolek, L S de Vries, A M van Loon

Affiliation

¹ Department of Virology, Eijkman-Winkler Centre, Utrecht, The Netherlands. ruzena.stranska@umassmed.edu

Abstract

Sequence analysis of the UL144 gene of human cytomegalovirus (CMV) was used to investigate the epidemiology of CMV infections in preterm infants. Nosocomial transmission of CMV from congenitally infected infant to preterm twins was excluded based on distinct molecular profiles of CMV strains. Indistinguishable molecular profiles between strains from the mother and the infant indicated postnatal acquisition of CMV through breastfeeding.

Publication types

Case Reports

MeSH terms

Base Sequence
Breast Feeding / adverse effects
Cross Infection / epidemiology
Cross Infection / transmission
Cross Infection / virology
Cytomegalovirus / classification*
Cytomegalovirus / genetics*
Cytomegalovirus / isolation & purification
Cytomegalovirus Infections / epidemiology*
Cytomegalovirus Infections / transmission
Cytomegalovirus Infections / virology*
DNA Primers / genetics
DNA, Viral / genetics
Female
Genes, Viral
Genotype
Humans
Infant, Newborn
Infant, Premature
Membrane Glycoproteins / genetics*
Milk, Human / virology
Molecular Epidemiology
Netherlands / epidemiology
Viral Proteins / genetics*

Substances

DNA Primers
DNA, Viral
Membrane Glycoproteins
UL144 ORF protein, Human herpesvirus 5
Viral Proteins