Gabapentin-induced coma in a patient with renal failure

Hemodial Int. 2006 Apr;10(2):168-9. doi: 10.1111/j.1542-4758.2006.00089.x.

Abstract

We describe a 60-year-old woman who became comatose after a single dose of gabapentin for right-sided sciatalgia. The patient was improved by hemodialysis. Gabapentin toxicity should be considered when mental status changes develop in patients with renal failure after even a single dose.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Amines / adverse effects*
  • Amines / therapeutic use
  • Coma / chemically induced*
  • Coma / physiopathology
  • Cyclohexanecarboxylic Acids / adverse effects*
  • Cyclohexanecarboxylic Acids / therapeutic use
  • Dose-Response Relationship, Drug
  • Female
  • Follow-Up Studies
  • Gabapentin
  • Humans
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / diagnosis*
  • Middle Aged
  • Risk Assessment
  • Sciatica / drug therapy*
  • Sciatica / etiology
  • gamma-Aminobutyric Acid / adverse effects*
  • gamma-Aminobutyric Acid / therapeutic use

Substances

  • Amines
  • Cyclohexanecarboxylic Acids
  • gamma-Aminobutyric Acid
  • Gabapentin