Abstract
We describe a 60-year-old woman who became comatose after a single dose of gabapentin for right-sided sciatalgia. The patient was improved by hemodialysis. Gabapentin toxicity should be considered when mental status changes develop in patients with renal failure after even a single dose.
MeSH terms
-
Administration, Oral
-
Amines / adverse effects*
-
Amines / therapeutic use
-
Coma / chemically induced*
-
Coma / physiopathology
-
Cyclohexanecarboxylic Acids / adverse effects*
-
Cyclohexanecarboxylic Acids / therapeutic use
-
Dose-Response Relationship, Drug
-
Female
-
Follow-Up Studies
-
Gabapentin
-
Humans
-
Kidney Failure, Chronic / complications
-
Kidney Failure, Chronic / diagnosis*
-
Middle Aged
-
Risk Assessment
-
Sciatica / drug therapy*
-
Sciatica / etiology
-
gamma-Aminobutyric Acid / adverse effects*
-
gamma-Aminobutyric Acid / therapeutic use
Substances
-
Amines
-
Cyclohexanecarboxylic Acids
-
gamma-Aminobutyric Acid
-
Gabapentin