This column is a response to Reed and Rolfe's column in the January 2006 issue of Nursing Science Quarterly. The authors present their views about Reed and Rolfe's ideas by focusing their discussion and questions on three main topics: the impact of nurses' conceptual thinking, values, and culture on their perspectives and experiences; the reality that nursing theory-guided practice is already a meaningful reality in nursing; and the belief that in order not to limit knowledge development, science must be viewed as more than a study of proximal causes.