Successful caspofungin treatment of multidrug resistant Candida parapsilosis septicaemia in an extremely low birth weight neonate

Mycoses. 2006 May;49(3):242-5. doi: 10.1111/j.1439-0507.2006.01220.x.

Abstract

Candida septicaemia with multidrug resistance is an uncommon event in preterm neonates. We present an extremely low birth weight infant (gestational age of 27 weeks, birth weight of 980 g) who developed congenital Candida parapsilosis septicaemia. Because the fungus was resistant both to amphotericin B and fluconazole, caspofungin was chosen for therapy. The fungus was successfully eradicated without any clinical or laboratory adverse effects.

Publication types

  • Letter

MeSH terms

  • Antifungal Agents / administration & dosage
  • Antifungal Agents / therapeutic use*
  • Candida / drug effects*
  • Candidiasis / congenital
  • Candidiasis / drug therapy
  • Candidiasis / microbiology
  • Caspofungin
  • Drug Resistance, Multiple, Fungal*
  • Echinocandins
  • Female
  • Fungemia / congenital
  • Fungemia / drug therapy*
  • Fungemia / microbiology
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / drug therapy*
  • Infant, Premature, Diseases / microbiology
  • Infant, Very Low Birth Weight*
  • Lipopeptides
  • Male
  • Peptides, Cyclic / administration & dosage
  • Peptides, Cyclic / therapeutic use*
  • Pregnancy
  • Treatment Outcome

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Peptides, Cyclic
  • Caspofungin