Severe limb abnormalities after chorion villus sampling at 56-66 days' gestation

H V Firth; P A Boyd; P Chamberlain; I Z MacKenzie; R H Lindenbaum; S M Huson

doi:10.1016/0140-6736(91)91374-4

Severe limb abnormalities after chorion villus sampling at 56-66 days' gestation

Lancet. 1991 Mar 30;337(8744):762-3. doi: 10.1016/0140-6736(91)91374-4.

Authors

H V Firth¹, P A Boyd, P Chamberlain, I Z MacKenzie, R H Lindenbaum, S M Huson

Affiliation

¹ Department of Medical Genetics, Churchill Hospital, Oxford, UK.

PMID: 1672394
DOI: 10.1016/0140-6736(91)91374-4

Abstract

Among 289 pregnancies in which chorion villus sampling (CVS) was carried out at 56-66 days' gestation, 5 babies with severe limb abnormalities were subsequently identified. 4 had oromandibular-limb hypogenesis syndromes, and the other had a terminal transverse limb reduction defect. This high incidence raises the possibility that CVS was an aetiological factor for these developmental anomalies.

MeSH terms

Abnormalities, Multiple / etiology*
Chorionic Villi Sampling / adverse effects*
Female
Gestational Age*
Humans
Limb Deformities, Congenital*
Pregnancy
Pregnancy Trimester, First
Syndrome