Increased frequency of HLA-DRw14b(w6)-associated RFLP in Greenlanders of Eskimo origin

Tissue Antigens. 1991 Mar;37(3):127-9. doi: 10.1111/j.1399-0039.1991.tb01857.x.

Abstract

HLA-DR typing by the restriction fragment length polymorphism (RFLP) technique of 42 Greenlanders living in northern Jutland, Denmark, revealed a phenotype frequency of 33.3% for HLA-DRw14b(w6), which is significantly different from the frequency of 0.0% observed among 98 Danes of Caucasian origin. When comparing the two populations, the frequency of other HLA-DRB allogenotypes show insignificant variations. Since HLA-DRw14b(w6) is carried by approximately one-third of the Greenlanders tested, this allogenotype may serve as a useful marker in further anthropological and immunogenetic studies.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Denmark
  • Gene Frequency
  • Genotype
  • Greenland / ethnology
  • HLA-DR Antigens / genetics*
  • HLA-DR Serological Subtypes
  • Humans
  • Inuit / genetics*
  • Polymorphism, Restriction Fragment Length*

Substances

  • HLA-DR Antigens
  • HLA-DR Serological Subtypes
  • HLA-DR14