Abstract
Thymic stromal lymphopoietin, a four helix-bundle cytokine, is expressed mainly by barrier epithelial cells and is a potent activator of several cell types, particularly myeloid dendritic cells. TSLP influences the outcome of interactions between dendritic cells and CD4+ thymocytes and T cells in many situations, such as the regulation of the positive selection of regulatory T cells, maintenance of peripheral CD4+ T cell homeostasis and induction of CD4+ T cell-mediated allergic inflammation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cell Movement
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Clonal Deletion / physiology
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Cytokines / chemistry
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Cytokines / physiology*
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Dendritic Cells / cytology
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Dendritic Cells / immunology
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Dermatitis, Atopic / immunology
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Dermatitis, Atopic / pathology
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Dimerization
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Epithelial Cells / metabolism
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Homeostasis
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Humans
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Hypersensitivity, Immediate / immunology
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Hypersensitivity, Immediate / pathology
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Immunoglobulins
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Inflammation / immunology
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Membrane Glycoproteins / physiology
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Mice
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OX40 Ligand
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Receptors, Cytokine / physiology
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Receptors, Interleukin-7 / chemistry
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Signal Transduction
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Stromal Cells / metabolism
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T-Lymphocyte Subsets / cytology*
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T-Lymphocyte Subsets / immunology
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Thymic Stromal Lymphopoietin
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Thymus Gland / metabolism
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Tumor Necrosis Factors / physiology
Substances
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CRLF2 protein, human
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Cytokines
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Immunoglobulins
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Membrane Glycoproteins
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OX40 Ligand
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Receptors, Cytokine
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Receptors, Interleukin-7
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TNFSF4 protein, human
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Tslpr protein, mouse
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Tumor Necrosis Factors
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interleukin-7 receptor, alpha chain
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Thymic Stromal Lymphopoietin