Linearity and time-scale invariance of the creep function in living cells

J R Soc Interface. 2004 Nov 22;1(1):91-7. doi: 10.1098/rsif.2004.0010.

Abstract

We report here the creep function measured in three cell types, after a variety of interventions, and over three time decades (from 3 ms to 3.2 s). In each case the response conformed to a power law, implying that no distinct molecular relaxation times or time constants could characterize the response. These results add to a growing body of evidence that stands in contrast to widely used viscoelastic models featuring at most a few time constants. We show instead that the ability of the matrix to deform is time-scale invariant and characterized by only one parameter: the power law exponent that controls the transition between solid-like and liquid-like behaviour. Moreover, we validate linearity by comparison of measurements in the time and frequency domains.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Cell Movement / physiology*
  • Cell Size
  • Cells, Cultured
  • Computer Simulation
  • Elasticity
  • Humans
  • Kinetics
  • Linear Models
  • Models, Biological*
  • Myocytes, Smooth Muscle / cytology*
  • Myocytes, Smooth Muscle / physiology*
  • Stress, Mechanical
  • Time Factors
  • Viscosity