Statin use before by-pass surgery decreases the incidence and shortens the duration of postoperative atrial fibrillation

Cardiology. 2007;107(2):117-21. doi: 10.1159/000094589. Epub 2006 Jul 18.

Abstract

Background: The aim of the present observational study is to search the incidence of postoperative atrial fibrillation (AF) in patients with or without preoperative statin treatment.

Methods and results: The population consisted of 362 consecutive patients (267 on and 95 not on statin). Diabetes mellitus was more frequent in statin group (p = 0.03). Other demographic and procedural variables were similar in the both groups (All p > 0.05). Postoperative AF was less frequent and its duration was shorter in statin group compared to non-statin group (p = 0.03 and 0.0001, respectively). The Kaplan-Meier analysis showed the protective effect of statins against the risk of developing AF (p = 0.01).

Conclusion: Statin treatment before the by-pass surgery decreases the incidence and shortens the duration of postoperative AF.

MeSH terms

  • Aged
  • Atrial Fibrillation / epidemiology
  • Atrial Fibrillation / etiology*
  • Atrial Fibrillation / prevention & control*
  • Coronary Artery Bypass / adverse effects*
  • Female
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
  • Incidence
  • Inflammation
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Proportional Hazards Models
  • Risk

Substances

  • Hydroxymethylglutaryl-CoA Reductase Inhibitors