Abstract
A series of 2-{[2'-(3''-chloro-2''-oxo-4''-substitutedaryl-1''-azetidinyl)-1',3'-thiazol-4'-yl] thio}benzothiazoles (4a-4e) and 2-{[(2'-(2''-substitutedaryl-4''-thiazolidinon-3''-yl)-1',3'-thiazol-4'-yl]thio}benzothiazoles (5a-5e) have been synthesized from 2-[(2'-substitutedarylidenylimino-1',3'-thiazol-4'-yl)thio]benzothiazoles (3a-3e). The structure of these compounds has been elucidated by elemental (C, H, N) and spectral (IR, (1)H-NMR, Mass) analysis. Furthermore, compounds 3a-3e, 4a-4e, and 5a-5e were screened for insecticidal activity against Periplaneta americana and antifungal, antibacterial activities in vitro against different strains of fungi and bacteria. Out of the fifteen compounds tested, compound 5b, 2-{[2'-(2''-p-hydroxy-m-methoxyphenyl)-4''-thiazolidinon-3''-yl)-1',3'-thiazol-4'-yl]thio}benzothiazole, was found to possess most prominent insecticidal activity.
MeSH terms
-
Animals
-
Anti-Bacterial Agents / analysis
-
Anti-Bacterial Agents / chemical synthesis*
-
Anti-Bacterial Agents / toxicity
-
Antifungal Agents / analysis
-
Antifungal Agents / chemical synthesis*
-
Antifungal Agents / toxicity
-
Azetidines / analysis
-
Azetidines / chemical synthesis*
-
Azetidines / toxicity
-
Benzothiazoles / analysis
-
Benzothiazoles / chemical synthesis*
-
Benzothiazoles / toxicity
-
Candida / drug effects
-
Candida / growth & development
-
Chloramphenicol / standards
-
Chloramphenicol / toxicity
-
Escherichia coli / drug effects
-
Escherichia coli / growth & development
-
Fluconazole / standards
-
Fluconazole / toxicity
-
Insecticides / analysis
-
Insecticides / chemical synthesis*
-
Insecticides / toxicity
-
Molecular Structure
-
Parathion / standards
-
Parathion / toxicity
-
Periplaneta / drug effects
-
Periplaneta / growth & development
-
Staphylococcus aureus / drug effects
-
Staphylococcus aureus / growth & development
Substances
-
Anti-Bacterial Agents
-
Antifungal Agents
-
Azetidines
-
Benzothiazoles
-
Insecticides
-
Parathion
-
Chloramphenicol
-
Fluconazole