Abstract
Resistance to beta-lactams and quinolones in two isogenic Enterobacter cloacae isolates was studied. One was susceptible to cefoxitin and amoxicillin-clavulanate. The other one showed its natural beta-lactam resistance pattern. Both isolates had a nonfunctional AmpR regulator. However, within the second one, the presence of a plasmid carrying ampR and qnrA1 allowed reversion to the wild-type beta-lactam resistance phenotype and decreased susceptibility to fluoroquinolones.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amoxicillin-Potassium Clavulanate Combination / pharmacology
-
Bacterial Proteins / genetics*
-
Cefoxitin / pharmacology
-
Enterobacter cloacae / drug effects
-
Enterobacter cloacae / genetics*
-
Enterobacter cloacae / isolation & purification
-
Enterobacteriaceae Infections / microbiology
-
Humans
-
Microbial Sensitivity Tests
-
Plasmids / genetics
-
Polymerase Chain Reaction
-
Quinolones / pharmacology
-
beta-Lactam Resistance / genetics*
Substances
-
Bacterial Proteins
-
Quinolones
-
AmpR protein, Bacteria
-
Cefoxitin
-
Amoxicillin-Potassium Clavulanate Combination