Abstract
From days 30-120 after birth, 59 BB rats were treated with water (n = 20) or FK 506 in intragastric doses of 1 mg.kg-1.day-1 (n = 19) or 2 mg.kg-1.day-1 (n = 20). Diabetes developed in 75, 15, and 0% of the 3 groups, respectively. Animals protected from diabetes by FK 506 had normal intraperitoneal glucose tolerance tests, virtual absence histopathologically of autoimmune insulitis, and normal pancreatic insulin content. Forty-five to 75 days after stopping FK 506, approximately 75% of the rats that were diabetes free at 120 days remained so.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology*
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Autoimmune Diseases / pathology
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Autoimmune Diseases / prevention & control
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Blood Glucose / analysis
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Cyclosporins / pharmacology
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Diabetes Mellitus, Experimental / pathology
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Diabetes Mellitus, Experimental / prevention & control*
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Dose-Response Relationship, Drug
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Glucose Tolerance Test
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Guinea Pigs
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Immunosuppressive Agents / pharmacology*
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Insulin / analysis
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Interleukin-2 / genetics
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Interleukin-3 / genetics
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Pancreas / chemistry
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Pancreas / pathology
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RNA, Messenger / drug effects
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RNA, Messenger / genetics
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Radioimmunoassay
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Rats
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Rats, Inbred BB
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Rats, Inbred Strains
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Tacrolimus
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Transcription, Genetic / drug effects
Substances
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Anti-Bacterial Agents
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Blood Glucose
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Cyclosporins
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Immunosuppressive Agents
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Insulin
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Interleukin-2
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Interleukin-3
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RNA, Messenger
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Tacrolimus