Age dependence of adenovirus-specific neutralizing antibody titers in individuals from sub-Saharan Africa

J Clin Microbiol. 2006 Oct;44(10):3781-3. doi: 10.1128/JCM.01249-06.

Abstract

We assessed neutralizing antibody titers to adenovirus serotype 5 (Ad5) and six rare adenovirus serotypes, serotypes 11, 35, 50, 26, 48, and 49, in pediatric populations in sub-Saharan Africa. We observed a clear age dependence of Ad5-specific neutralizing antibody titers. These data will help to guide the development of Ad vector-based vaccines for human immunodeficiency virus type 1 and other pathogens.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenovirus Infections, Human / blood
  • Adenovirus Infections, Human / epidemiology
  • Adenovirus Infections, Human / immunology*
  • Adenoviruses, Human / immunology*
  • Adolescent
  • Africa South of the Sahara / epidemiology
  • Aging*
  • Antibodies, Viral / blood*
  • Child
  • Child, Preschool
  • Humans
  • Infant
  • Infectious Disease Transmission, Vertical
  • Seroepidemiologic Studies

Substances

  • Antibodies, Viral