The expression of PRDI-BF1 beta isoform in multiple myeloma plasma cells

Haematologica. 2006 Nov;91(11):1579-80. Epub 2006 Oct 17.

Abstract

The PRDM1 gene, a master regulator of plasma cells (PC), can generate two transcription factor isoforms: PRDI-BF1alpha and PRDI-BF1beta. The present study shows that purified human normal PC have a significantly lower levels of PRDI-BF1beta expression than that in tumoral PC isolated from multiple myeloma (MM) (0.06+/-0.01 and 0.25+/-0.05, respectively; p<0.001). The role of this finding in MM is discussed.

Publication types

  • Comparative Study
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gene Expression Regulation, Neoplastic / genetics
  • Gene Expression Regulation, Neoplastic / physiology*
  • Humans
  • Multiple Myeloma / genetics
  • Multiple Myeloma / metabolism*
  • Plasma Cells / metabolism*
  • Positive Regulatory Domain I-Binding Factor 1
  • Protein Isoforms / biosynthesis
  • Protein Isoforms / genetics
  • Repressor Proteins / biosynthesis*
  • Repressor Proteins / genetics
  • Transcription Factors / biosynthesis*
  • Transcription Factors / genetics

Substances

  • Protein Isoforms
  • Repressor Proteins
  • Transcription Factors
  • PRDM1 protein, human
  • Positive Regulatory Domain I-Binding Factor 1