Synthesis of some bioactive 2-bromo-5-methoxy-N'-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives

K K Vijaya Raj; B Narayana; B V Ashalatha; N Suchetha Kumari; B K Sarojini

doi:10.1016/j.ejmech.2006.09.010

Synthesis of some bioactive 2-bromo-5-methoxy-N'-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives

Eur J Med Chem. 2007 Mar;42(3):425-9. doi: 10.1016/j.ejmech.2006.09.010. Epub 2006 Oct 30.

Authors

K K Vijaya Raj¹, B Narayana, B V Ashalatha, N Suchetha Kumari, B K Sarojini

Affiliation

¹ Department of Post-Graduate Studies and Research in Chemistry, Mangalore University, Mangalagangotri, Mangalore 574 199, Karnataka, India.

PMID: 17074422
DOI: 10.1016/j.ejmech.2006.09.010

Abstract

Eight novel 2-bromo-5-methoxy-N'-[4-(aryl)-1,3-thiazol-2-yl]benzohydrazide derivatives were prepared and characterized by analytical and spectral analyses. All the compounds were screened for their analgesic, antifungal and antibacterial activities and three of the compounds were screened for antiproliferative activity. Two of the newly synthesized compounds exhibited promising analgesic activity and one compound exhibited in vitro antiproliferative activity.

MeSH terms

Analgesics, Non-Narcotic / chemical synthesis*
Analgesics, Non-Narcotic / pharmacology*
Animals
Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / pharmacology*
Antifungal Agents / chemical synthesis*
Antifungal Agents / pharmacology*
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / pharmacology*
Bacteria / drug effects
Cell Line, Tumor
Drug Screening Assays, Antitumor
Female
Fungi / drug effects
Humans
Hydrazines / chemical synthesis*
Hydrazines / pharmacology*
Magnetic Resonance Spectroscopy
Male
Mice
Microbial Sensitivity Tests
Thiazoles / chemical synthesis*
Thiazoles / pharmacology*

Substances

Analgesics, Non-Narcotic
Anti-Bacterial Agents
Antifungal Agents
Antineoplastic Agents
Hydrazines
Thiazoles