Abstract
Tumor suppressor in lung cancer-1 (TSLC1) loss is common in many human cancers, including meningioma. In this study, we demonstrate that TSLC1 protein and RNA expression is lost in 60% to 65% of high-grade gliomas, and that TSLC1 reintroduction into glioma cells results in growth suppression. Moreover, Tslc1 loss in mice results in increased astrocyte proliferation in vivo and in vitro. These data indicate that TSLC1 functions as a glioma tumor suppressor.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Animals
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Astrocytes / metabolism
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Astrocytes / pathology
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Brain Neoplasms / genetics*
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Brain Neoplasms / metabolism
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Brain Neoplasms / physiopathology
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Cell Adhesion Molecule-1
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Cell Adhesion Molecules
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Cell Proliferation
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Cell Transformation, Neoplastic / genetics
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Down-Regulation / genetics
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Gene Expression Regulation, Neoplastic / genetics*
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Glioma / genetics*
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Glioma / metabolism
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Glioma / physiopathology
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Humans
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Immunoglobulins / genetics*
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Immunoglobulins / metabolism
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Membrane Proteins / genetics*
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Membrane Proteins / metabolism
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Mice
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Mice, Knockout
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Tumor Cells, Cultured
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Tumor Suppressor Proteins / genetics*
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Tumor Suppressor Proteins / metabolism
Substances
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CADM1 protein, human
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Cadm1 protein, mouse
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Cell Adhesion Molecule-1
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Cell Adhesion Molecules
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Immunoglobulins
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Membrane Proteins
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Tumor Suppressor Proteins