Abstract
We investigated the antibody response of DNA immunization with two mammalian codon optimized envelope glycoprotein genes, F and G, of Nipah virus in a mouse model. The results indicated that G gene immunization elicited more significant specific serum IgG response and neutralization antibody response than F gene did, suggesting that the G gene DNA immunization is a potential vaccine strategy against Nipah virus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antibodies, Viral / biosynthesis
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Henipavirus Infections / prevention & control
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Henipavirus Infections / transmission
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Henipavirus Infections / veterinary*
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Humans
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Immunization / veterinary
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Immunoglobulin G / biosynthesis
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Mice
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Nipah Virus / immunology*
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Vaccines, DNA / immunology*
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Viral Envelope Proteins / immunology
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Viral Fusion Proteins / immunology
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Viral Proteins / immunology*
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Viral Vaccines / immunology*
Substances
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Antibodies, Viral
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Immunoglobulin G
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Vaccines, DNA
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Viral Envelope Proteins
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Viral Fusion Proteins
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Viral Proteins
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Viral Vaccines
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attachment protein G