'Partial D' women with anti-D alloimmunization in pregnancy

Clin Lab Haematol. 1991;13(3):239-44. doi: 10.1111/j.1365-2257.1991.tb00278.x.

Abstract

We report five women with Rh 'partial D' who were found to have anti-D during pregnancy. Two patients were category IVa, their red cells typing as Go(a+); one was category VI; and two had a 'partial Du' which could not be categorized. The maternal anti-D concentration increased during four of the eight pregnancies studied, but none reached significant levels. Three of six D-positive cord blood samples had a positive direct antiglobulin test (DAGT). Although one baby became jaundiced, no treatment was required. The policy in the Oxford Region for the management of patients with a weak expression of D is outlined.

MeSH terms

  • England / epidemiology
  • Epitopes / immunology
  • Female
  • Fetal Blood / immunology
  • Humans
  • Incidence
  • Infant, Newborn
  • Isoantibodies / blood*
  • Pregnancy / immunology*
  • Pregnancy Outcome
  • Retrospective Studies
  • Rh Isoimmunization* / epidemiology
  • Rh-Hr Blood-Group System / immunology*

Substances

  • Epitopes
  • Isoantibodies
  • RH-antibodies
  • Rh-Hr Blood-Group System
  • Rho(D) antigen