Genetic screening for signal transduction in the era of network biology

Adam Friedman; Norbert Perrimon

doi:10.1016/j.cell.2007.01.007

Genetic screening for signal transduction in the era of network biology

Cell. 2007 Jan 26;128(2):225-31. doi: 10.1016/j.cell.2007.01.007.

Authors

Adam Friedman¹, Norbert Perrimon

Affiliation

¹ Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02175, USA.

PMID: 17254958
DOI: 10.1016/j.cell.2007.01.007

Abstract

In contrast to animal-based mutant phenotype assays, recent biochemical and quantitative genetic studies have identified hundreds of potential regulators of known signaling pathways. We discuss the discrepancy between previous models and new data, put forward a different signaling conceptual framework incorporating time-dependent quantitative contributions, and suggest how this new framework can impact our study of human disease.

Publication types

Review

MeSH terms

Animals
Computational Biology / methods
Computational Biology / trends
Gene Expression Regulation / genetics
Gene Regulatory Networks / genetics*
Genetic Diseases, Inborn / genetics
Genetic Diseases, Inborn / physiopathology
Genetic Diseases, Inborn / therapy
Genetic Testing / methods*
Genetic Testing / trends
Humans
Molecular Biology / methods*
Molecular Biology / trends
Neoplasms / therapy
Signal Transduction / genetics*