Trifurcating coronary artery disease is a complex atherosclerotic process involving the origin of one or more of three side branches arising from a main coronary artery vessel or trunk (MT), with or without involvement of the MT itself. To date, there is no classification or standardized methodology to treat trifurcation disease. In this report, we propose a new, simplified classification system for trifurcation coronary artery disease and describe various methodologies to treat the various types.