Levobupivacaine-induced seizures and cardiovascular collapse treated with Intralipid

Anaesthesia. 2007 May;62(5):516-8. doi: 10.1111/j.1365-2044.2007.05065.x.

Abstract

Lipid emulsion has been used in the successful treatment of local anaesthetic-induced cardiovascular collapse in animals and in two cases of cardiac arrest in humans. Previous reports of levobupivacaine toxicity in humans have been characterised by neurological signs and symptoms, without serious cardiovascular events. We present a case in which presumed intravenous injection of levobupivacaine led to neurological and cardiovascular consequences. This was treated successfully by resuscitation that included intravenous Intralipid infusion.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Anesthetics, Local / adverse effects*
  • Bupivacaine / adverse effects
  • Bupivacaine / analogs & derivatives
  • Fat Emulsions, Intravenous / therapeutic use*
  • Female
  • Heart Arrest / chemically induced*
  • Heart Arrest / therapy
  • Humans
  • Intraoperative Complications / therapy
  • Levobupivacaine
  • Nerve Block / adverse effects
  • Nerve Block / methods
  • Seizures / chemically induced*
  • Seizures / therapy

Substances

  • Anesthetics, Local
  • Fat Emulsions, Intravenous
  • Levobupivacaine
  • Bupivacaine