Methicillin-resistant Staphylococcus aureus pneumonia after thoracic surgery: successful treatment with linezolid after failed vancomycin therapy

Daniel Salerno; Bobbak Vahid; Paul E Marik

doi:10.1016/j.athoracsur.2006.11.068

Methicillin-resistant Staphylococcus aureus pneumonia after thoracic surgery: successful treatment with linezolid after failed vancomycin therapy

Ann Thorac Surg. 2007 May;83(5):1888-91. doi: 10.1016/j.athoracsur.2006.11.068.

Authors

Daniel Salerno¹, Bobbak Vahid, Paul E Marik

Affiliation

¹ Department of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

PMID: 17462428
DOI: 10.1016/j.athoracsur.2006.11.068

Abstract

We describe 3 patients with methicillin-resistant Staphylococcus aureus, hospital-acquired pneumonia who demonstrated a microbiological and clinical failure with vancomycin despite adequate trough levels. All 3 patients were cured with linezolid.

MeSH terms

Acetamides / therapeutic use*
Aged
Aged, 80 and over
Anti-Infective Agents / therapeutic use*
Cross Infection / drug therapy
Cross Infection / etiology
Female
Humans
Linezolid
Male
Methicillin Resistance*
Oxazolidinones / therapeutic use*
Pneumonia, Staphylococcal / drug therapy*
Pneumonia, Staphylococcal / etiology
Staphylococcus aureus*
Thoracic Surgical Procedures / adverse effects
Treatment Failure
Treatment Outcome
Vancomycin / therapeutic use

Substances

Acetamides
Anti-Infective Agents
Oxazolidinones
Vancomycin
Linezolid