Purpose: To investigate the ability of frequency doubling technology (FDT) perimetry to identify eyes with a localized retinal nerve fiber layer (RNFL) defect and normal Humphrey C30-2 SITA-Standard visual field (HVF).
Design: Retrospective case-control study.
Methods: Fifty-four eyes were divided into two groups, an abnormal (n = 29) and a normal (n = 25) FDT perimetry group. Approximation of the RNFL defect to the macula (angle alpha) and width of the defect (angle beta) were measured by RNFL photograph and compared between two groups.
Results: Angle alpha and angle beta were significantly different between two groups (P < .001 by Mann-Whitney U test, respectively). A multivariate logistic regression analysis demonstrated that only angle beta was significantly associated with FDT perimetry abnormalities (P = .002).
Conclusions: Only 53.7% of the eyes with a localized RNFL defect and normal HVF had visual field abnormalities identified by FDT perimetry. Width of the RNFL defect was more strongly associated with FDT perimetry abnormalities than location of the defect.