Malignant transformation of hamster brain cells in vitro by human papovavirus Bk

J Natl Cancer Inst. 1976 Mar;56(3):671-3. doi: 10.1093/jnci/56.3.671.

Abstract

Human papovavirus BK caused the malignant transformation in vitro of brain cells prepared from newborn hamsters. The transformed cells produced BK virus T antigen and grew as tumors after sc inoculation ito hamsters that developed antibodies to BK virus T antigen. The histopathology of the tumors revealed an undifferentiated glioma.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Animals, Newborn
  • Antibodies, Viral / analysis
  • Brain
  • Cell Transformation, Neoplastic*
  • Cells, Cultured
  • Cricetinae
  • Glioma / etiology
  • Glioma / immunology
  • Neoplasms, Experimental / etiology
  • Neoplasms, Experimental / immunology
  • Polyomavirus* / immunology

Substances

  • Antibodies, Viral