Penetration of amphotericin B lipid formulations into pleural effusion

Antimicrob Agents Chemother. 2007 Nov;51(11):4211-3. doi: 10.1128/AAC.01087-07. Epub 2007 Sep 4.

Abstract

The penetration of the amphotericin B (AMB) lipid formulations (liposomal AMB, AMB colloidal dispersion, and AMB lipid complex formulations) into pleural effusions in seven critically ill patients was assessed. AMB was detected in all pleural effusion samples at concentrations ranging from 0.02 to 0.43 microg/ml. The penetration ratio was 3 to 44%.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Amphotericin B / blood
  • Amphotericin B / pharmacokinetics*
  • Antifungal Agents / blood
  • Antifungal Agents / pharmacokinetics
  • Critical Illness
  • Drug Combinations
  • Female
  • Humans
  • Male
  • Middle Aged
  • Phosphatidylcholines / blood
  • Phosphatidylcholines / pharmacokinetics*
  • Phosphatidylglycerols / blood
  • Phosphatidylglycerols / pharmacokinetics*
  • Pleural Effusion / metabolism*

Substances

  • Antifungal Agents
  • Drug Combinations
  • Phosphatidylcholines
  • Phosphatidylglycerols
  • liposomal amphotericin B
  • Amphotericin B