Reduced ventral anterior cingulate and amygdala volumes in medication-naïve females with major depressive disorder: A voxel-based morphometric magnetic resonance imaging study

Yanqing Tang; Fei Wang; Guangrong Xie; Jun Liu; Lehua Li; Linyan Su; Ying Liu; Xian Hu; Zhong He; Hilary P Blumberg

doi:10.1016/j.pscychresns.2007.03.005

Reduced ventral anterior cingulate and amygdala volumes in medication-naïve females with major depressive disorder: A voxel-based morphometric magnetic resonance imaging study

Psychiatry Res. 2007 Oct 15;156(1):83-6. doi: 10.1016/j.pscychresns.2007.03.005. Epub 2007 Sep 6.

Authors

Yanqing Tang¹, Fei Wang, Guangrong Xie, Jun Liu, Lehua Li, Linyan Su, Ying Liu, Xian Hu, Zhong He, Hilary P Blumberg

Affiliation

¹ Department of Psychiatry, The Second Xiangya Hospital, Central South University, 86, Mid-Renmin Road, Changsha, Hunan 410011, PR China.

PMID: 17825533
DOI: 10.1016/j.pscychresns.2007.03.005

Abstract

High resolution magnetic resonance imaging and voxel-based morphometry were used to compare regional gray matter volumes between 14 medication-naïve female participants with a first episode of major depressive disorder (MDD) and 13 female healthy comparison participants (HC). Volumes of bilateral ventral anterior cingulate cortex (vACC) and right amygdala were significantly smaller in the MDD group than in the HC group. These results suggest that volume reductions in vACC and amygdala in females with MDD are present at illness onset.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Amygdala / anatomy & histology*
Depressive Disorder, Major / diagnosis
Depressive Disorder, Major / psychology*
Diagnostic and Statistical Manual of Mental Disorders
Female
Gyrus Cinguli / anatomy & histology*
Humans
Magnetic Resonance Imaging*
Severity of Illness Index