Abstract
Septicemia caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae was associated with high mortality in Tanzanian children. Conjugation experiments on the SHV-12-producing Enterobacteriaceae isolates showed that ESBL-encoding genes were transferred on large plasmids together with genes encoding resistance to aminoglycosides, resistance to ceftazidime, gentamicin, doxycycline, trimethoprim-sulfamethoxazole, and chloramphenicol.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Child
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Drug Resistance, Multiple, Bacterial / genetics
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Enterobacteriaceae / drug effects
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Enterobacteriaceae / enzymology
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Enterobacteriaceae / genetics*
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Enterobacteriaceae Infections* / drug therapy
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Enterobacteriaceae Infections* / epidemiology
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Enterobacteriaceae Infections* / genetics
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Humans
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Microbial Sensitivity Tests
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Plasmids / classification
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Plasmids / drug effects
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Plasmids / genetics*
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Prospective Studies
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Sepsis / drug therapy
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Sepsis / epidemiology
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Sepsis / microbiology*
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Tanzania / epidemiology
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beta-Lactam Resistance / genetics*
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beta-Lactamases / genetics*
Substances
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beta-lactamase SHV-12
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beta-Lactamases