Extended-spectrum beta-lactamase-type SHV-12-producing Enterobacteriaceae causing septicemia in Tanzanian children: vectors for horizontal transfer of antimicrobial resistance

Diagn Microbiol Infect Dis. 2007 Nov;59(3):351-4. doi: 10.1016/j.diagmicrobio.2007.06.015. Epub 2007 Sep 18.

Abstract

Septicemia caused by extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae was associated with high mortality in Tanzanian children. Conjugation experiments on the SHV-12-producing Enterobacteriaceae isolates showed that ESBL-encoding genes were transferred on large plasmids together with genes encoding resistance to aminoglycosides, resistance to ceftazidime, gentamicin, doxycycline, trimethoprim-sulfamethoxazole, and chloramphenicol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Drug Resistance, Multiple, Bacterial / genetics
  • Enterobacteriaceae / drug effects
  • Enterobacteriaceae / enzymology
  • Enterobacteriaceae / genetics*
  • Enterobacteriaceae Infections* / drug therapy
  • Enterobacteriaceae Infections* / epidemiology
  • Enterobacteriaceae Infections* / genetics
  • Humans
  • Microbial Sensitivity Tests
  • Plasmids / classification
  • Plasmids / drug effects
  • Plasmids / genetics*
  • Prospective Studies
  • Sepsis / drug therapy
  • Sepsis / epidemiology
  • Sepsis / microbiology*
  • Tanzania / epidemiology
  • beta-Lactam Resistance / genetics*
  • beta-Lactamases / genetics*

Substances

  • beta-lactamase SHV-12
  • beta-Lactamases