[Indinavir-associated tubulointerstitial renal disease]

Raymonde F Gagnon; Amira Mehio; Sameena Iqbal; Christos M Tsoukas

doi:10.1016/j.nephro.2007.07.004

[Indinavir-associated tubulointerstitial renal disease]

Nephrol Ther. 2007 Dec;3(7):461-2. doi: 10.1016/j.nephro.2007.07.004. Epub 2007 Sep 18.

[Article in French]

Authors

Raymonde F Gagnon¹, Amira Mehio, Sameena Iqbal, Christos M Tsoukas

Affiliation

¹ Département de médecine, centre hospitalier de l'université McGill, Montréal, Canada. raymonde.gagnon@muhc.mcgill.ca

PMID: 18048001
DOI: 10.1016/j.nephro.2007.07.004

Abstract

Indinavir, used for the treatment of HIV disease, forms distinctive crystals in the urine. The crystalluria has been associated principally with several urinary tract abnormalities which may require discontinuation of the drug. We present a case of progressive leucocyturia and renal impairment occurring during indinavir treatment which illustrates vividly the impact of the crystalluria on the tubulointerstitial renal compartment.

Publication types

Case Reports
English Abstract

MeSH terms

Adult
Crystallization
Female
HIV Infections / complications
HIV Infections / drug therapy
HIV Protease Inhibitors / adverse effects*
HIV Protease Inhibitors / chemistry
HIV Protease Inhibitors / urine
Humans
Indinavir / adverse effects*
Indinavir / chemistry
Indinavir / urine
Leukocytes
Nephritis, Interstitial / chemically induced*
Urine / chemistry
Urine / cytology

Substances

HIV Protease Inhibitors
Indinavir