A seminal finding for understanding HIV transmission

Nadia R Roan; Warner C Greene

doi:10.1016/j.cell.2007.11.030

A seminal finding for understanding HIV transmission

Cell. 2007 Dec 14;131(6):1044-6. doi: 10.1016/j.cell.2007.11.030.

Authors

Nadia R Roan¹, Warner C Greene

Affiliation

¹ Gladstone Institute of Virology and Immunology, University of California, San Francisco, 1650 Owens Street, San Francisco, CA 94158, USA. nroan@gladstone.ucsf.edu

PMID: 18083095
DOI: 10.1016/j.cell.2007.11.030

Abstract

Although the worldwide incidence of HIV infection is high, the retrovirus displays a surprisingly low infectivity in vitro. As a potential explanation for this discrepancy, Münch et al. (2007) now identify and characterize a factor found in human semen that under certain conditions can enhance HIV infectivity by more than 100,000-fold.

Publication types

Comment

MeSH terms

Acid Phosphatase
Amyloid / physiology*
HIV Infections / transmission*
Humans
Peptide Fragments / physiology
Protein Tyrosine Phosphatases / chemistry*
Semen / metabolism*
Semen / physiology
Sexually Transmitted Diseases, Viral
Viral Load

Substances

Amyloid
Peptide Fragments
Acid Phosphatase
prostatic acid phosphatase
Protein Tyrosine Phosphatases