The Nuclear Receptor Signaling Atlas (NURSA) was established as a trans-National Institutes of Health resource to develop, accrue, and communicate information about the nuclear receptor (NR) superfamily of ligand-dependent and -independent transcription factors. NRs have broad involvement in the regulation of development, reproduction, and metabolism. Receptors for thyroid hormones represent important members of the NR superfamily with key roles in development and homeostasis. NURSA has attempted to create a resource for information on NRs, associated coregulators, and ligands. The Web portal (www.NURSA.org) creates a window through which the general research community can gain access to data generated by NURSA investigators and linked from other sources. The molecule pages provide detailed curated information about the NR superfamily and allow the user to search for information useful to their own specific research problems. With the application of bioinformatics solutions, analyses of large amounts of data can be utilized to validate and/or create hypotheses that will ultimately lead to translational opportunities to take information about NRs, in general, and thyroid receptors, in particular to potential clinical applications.