Assignment of beta-hexosaminidase A alpha-subunit to human chromosomal region 15q23----q24

Cytogenet Cell Genet. 1991;56(3-4):164. doi: 10.1159/000133077.

Abstract

Tay-Sachs disease results from a mutation in the alpha subunit of beta-hexosaminidase. Using a cDNA clone, we have mapped the gene to 15q23----q24 by in situ hybridization.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, Pair 15 / ultrastructure*
  • DNA Probes
  • Genes
  • Humans
  • Nucleic Acid Hybridization
  • Tay-Sachs Disease / genetics*
  • beta-N-Acetylhexosaminidases / genetics*

Substances

  • DNA Probes
  • beta-N-Acetylhexosaminidases