Abstract
Tay-Sachs disease results from a mutation in the alpha subunit of beta-hexosaminidase. Using a cDNA clone, we have mapped the gene to 15q23----q24 by in situ hybridization.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Chromosome Mapping
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Chromosomes, Human, Pair 15 / ultrastructure*
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DNA Probes
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Genes
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Humans
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Nucleic Acid Hybridization
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Tay-Sachs Disease / genetics*
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beta-N-Acetylhexosaminidases / genetics*
Substances
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DNA Probes
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beta-N-Acetylhexosaminidases