Pharmacological neuroprotective therapy for acute spinal cord injury: state of the art

Mini Rev Med Chem. 2008 Mar;8(3):222-30. doi: 10.2174/138955708783744056.

Abstract

After spinal cord injury, a number of destructive events developed immediately after the primary insult increase tissue damage. Several therapeutic approaches are directed to neutralize these phenomena. The present manuscript revises diverse pharmacological treatments used to promote neuroprotection, both in clinical and experimental acute spinal cord injuries.

Publication types

  • Review

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Calpain / antagonists & inhibitors
  • Calpain / metabolism
  • Cyclooxygenase Inhibitors / chemistry
  • Cyclooxygenase Inhibitors / therapeutic use
  • Humans
  • Immunophilins / antagonists & inhibitors
  • Immunophilins / metabolism
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / pharmacology
  • Neuroprotective Agents / therapeutic use*
  • Spinal Cord Injuries / drug therapy*
  • Spinal Cord Injuries / pathology

Substances

  • Cyclooxygenase Inhibitors
  • Neuroprotective Agents
  • Calpain
  • Immunophilins