CD4+ T cell depletion in an untreated HIV type 1-infected human leukocyte antigen-B*5801-positive patient with an undetectable viral load

Clin Infect Dis. 2008 Apr 15;46(8):e78-82. doi: 10.1086/529387.

Abstract

We report a case of a patient infected with human immunodeficiency virus type 1 (HIV-1) for 20 years who has experienced CD4(+) T cell depletion in spite of maintaining undetectable viral loads. Our data suggest that immune activation can cause CD4(+) T cell depletion even when HIV-1 replication appears to be controlled by host factors.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • CD4-Positive T-Lymphocytes / immunology*
  • CD4-Positive T-Lymphocytes / metabolism
  • CD8-Positive T-Lymphocytes / immunology
  • CD8-Positive T-Lymphocytes / metabolism
  • Enzyme-Linked Immunosorbent Assay
  • HIV Infections / immunology*
  • HIV-1 / immunology*
  • HLA-B Antigens / genetics
  • Humans
  • Lymphocyte Depletion*
  • Male
  • Viral Load*

Substances

  • HLA-B Antigens
  • HLA-B*58:01 antigen
  • HLA-B57 antigen