Abstract
We report a case of a patient infected with human immunodeficiency virus type 1 (HIV-1) for 20 years who has experienced CD4(+) T cell depletion in spite of maintaining undetectable viral loads. Our data suggest that immune activation can cause CD4(+) T cell depletion even when HIV-1 replication appears to be controlled by host factors.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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CD4-Positive T-Lymphocytes / immunology*
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CD4-Positive T-Lymphocytes / metabolism
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CD8-Positive T-Lymphocytes / immunology
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CD8-Positive T-Lymphocytes / metabolism
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Enzyme-Linked Immunosorbent Assay
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HIV Infections / immunology*
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HIV-1 / immunology*
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HLA-B Antigens / genetics
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Humans
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Lymphocyte Depletion*
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Male
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Viral Load*
Substances
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HLA-B Antigens
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HLA-B*58:01 antigen
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HLA-B57 antigen