Abstract
Studies have shown various cardiotoxic effects of high-dose chemotherapy (HDC) used for conditioning before autologous bone marrow transplant (ABMT) including arrhythmias but only a transient small decrease in left ventricle ejection fraction (LVEF). To our knowledge, an acute dramatic decrease in LVEF after HDC preconditioning has never been reported. We report a patient presenting with an acutely symptomatic heart failure within 2 weeks of receiving HDC conditioning for ABMT with an LVEF drop from normal to <30%. With stringent management and follow-up with regular echocardiograms for medication reconciliation, 5 months later she regained her LVEF of 50%.
MeSH terms
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Acute Disease
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Antineoplastic Combined Chemotherapy Protocols / adverse effects*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use
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Bone Marrow Transplantation / adverse effects
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Bone Marrow Transplantation / methods*
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Cardiac Output
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Cyclophosphamide / adverse effects
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Dose-Response Relationship, Drug
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Drug Administration Schedule
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Echocardiography, Doppler
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Female
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Follow-Up Studies
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Heart Failure, Systolic / chemically induced*
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Heart Failure, Systolic / diagnostic imaging
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Humans
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Lymphoma, Large B-Cell, Diffuse / pathology
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Lymphoma, Large B-Cell, Diffuse / surgery*
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Middle Aged
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Recovery of Function
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Risk Assessment
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Severity of Illness Index
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Stroke Volume
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Time Factors
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Transplantation Conditioning / adverse effects*
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Transplantation Conditioning / methods
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Transplantation, Autologous
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Ventricular Dysfunction, Left / chemically induced
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Ventricular Dysfunction, Left / diagnostic imaging