Interaction of aflatoxin in the feed and immunization against selected infectious diseases in poultry. II. Effect on one-day-old layer chicks simultaneously vaccinated against Newcastle disease, infectious bronchitis and infectious bursal disease

M A Gabal; A H Azzam

doi:10.1080/03079459808419338

Interaction of aflatoxin in the feed and immunization against selected infectious diseases in poultry. II. Effect on one-day-old layer chicks simultaneously vaccinated against Newcastle disease, infectious bronchitis and infectious bursal disease

Avian Pathol. 1998;27(3):290-5. doi: 10.1080/03079459808419338.

Authors

M A Gabal¹, A H Azzam

Affiliation

¹ Department of Microbiology, Immunology and Preventive Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.

PMID: 18484000
DOI: 10.1080/03079459808419338

Abstract

A study was conducted to assess the effects of aflatoxin contaminated feed on the immunoresponse of one-day old layer chicks to attenuated live virus vaccines for Newcastle disease (ND), infectious bronchitis (IB) and infectious bursal disease (IBD). Concurrent exposure of chickens to 2tiO parts per billion (ppb) aflatoxin in feed and vaccination against ND, IB and IBD resulted in lack of adequate protection against subsequent experimental challenge, as assessed by antibody responses compared to chickens fed aflatoxin-free ration. The mortalities were higher in chickens fed 200 ppb of aflatoxin than in chickens fed on aflatoxin-free ration.