Interleukin-2 immediate type hypersensitivity?
J Dtsch Dermatol Ges. 2008 Nov;6(11):956-8.
doi: 10.1111/j.1610-0387.2008.06769.x.
Epub 2008 May 21.
[Article in
English,
German]
Affiliation
- 1 Department of Dermatology, Johannes Gutenberg University, Mainz, Germany.
Abstract
Two patients with metastatic malignant melanoma developed immediate type hypersensitivity-like symptoms while being treated with recombinant interleukin-(IL-)2 immunotherapy. Both patients showed positive skin prick tests to IL-2, enhanced basophil degranulation in vitro and responded to anti-histamines, but laboratory investigations suggested an IgE-independent, pseudoallergic mast cell degranulation against IL-2.
MeSH terms
-
Adult
-
Drug Eruptions / diagnosis*
-
Drug Eruptions / etiology*
-
Female
-
Humans
-
Interleukin-2 / adverse effects*
-
Interleukin-2 / therapeutic use
-
Male
-
Middle Aged