Tubercular mastitis in men: case report and systematic review

Am J Med. 2008 Jun;121(6):539-44. doi: 10.1016/j.amjmed.2008.01.026.

Abstract

Background: Tuberculous mastitis is usually reported in multiparous postpartum women and is an unusual cause of gynecomastia in adolescent men.

Methods: We describe an illustrative case and review all cases of tubercular mastitis reported in men in the English literature.

Results: Our search yielded 24 cases of male tubercular mastitis. Most presented with an isolated breast lump. Constitutional symptoms were rare (21.4%), and associated tuberculosis foci, mostly inactive, were seen in 43.8%. Breast parenchymal involvement, chest wall masses, pectoral muscle abscesses, cold abscesses tracking through the chest wall, and empyema necessitatis presented as breast lumps. Fine-needle aspiration cytology was the most common diagnostic modality, and acid-fast bacilli were demonstrable in a minority (33%). A combination of granulomatous mastitis, necrosis, and clinical response to antitubercular therapy was the most common mode of establishing the diagnosis. Most patients responded to antitubercular therapy alone.

Conclusion: Tubercular mastitis is a rare cause of breast masses in men, and a high index of suspicion can prevent diagnostic delays. Most patients respond to antitubercular therapy alone.

Publication types

  • Case Reports
  • Review
  • Systematic Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Antitubercular Agents / administration & dosage
  • Biopsy, Fine-Needle
  • Gynecomastia / diagnostic imaging
  • Gynecomastia / drug therapy
  • Gynecomastia / microbiology
  • Humans
  • Male
  • Mastitis / diagnostic imaging
  • Mastitis / drug therapy
  • Mastitis / microbiology*
  • Middle Aged
  • Radiography
  • Treatment Outcome
  • Tuberculosis / diagnosis*
  • Tuberculosis / diagnostic imaging
  • Tuberculosis / drug therapy

Substances

  • Antitubercular Agents