UCA1, a non-protein-coding RNA up-regulated in bladder carcinoma and embryo, influencing cell growth and promoting invasion

FEBS Lett. 2008 Jun 11;582(13):1919-27. doi: 10.1016/j.febslet.2008.05.012. Epub 2008 May 22.

Abstract

A non-protein-coding RNA, UCA1, has been cloned from human bladder TCC cell line BLZ-211 by using 5' and 3' RACE. The UCA1 full-length cDNA was 1442 bp. RT-PCR analysis indicated that UCA1 is an embryonic development and bladder cancer-associated RNA. The proliferative, migrative, invasive, and drug resistance behaviors of human bladder TCC cell line BLS-211 were enhanced by exogenous UCA1 expression in vitro. Several potential target genes of UCA1 were identified through microarray analysis. Moreover, the expression of UCA1 also increased tumorigenic potential of BLS-211 cells in nude mice. Results from the present study suggested that UCA1 might play a pivotal role in bladder cancer progression and embryonic development.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Carcinoma / genetics
  • Carcinoma / metabolism*
  • Carcinoma / pathology*
  • Cell Line, Tumor
  • Cell Movement / genetics
  • Cell Proliferation
  • Cloning, Molecular
  • Drug Resistance, Neoplasm / genetics
  • Embryo, Mammalian / metabolism*
  • Embryonic Development / genetics
  • Humans
  • Mice
  • Molecular Sequence Data
  • Neoplasm Invasiveness
  • Oligonucleotide Array Sequence Analysis
  • RNA, Long Noncoding
  • RNA, Untranslated / genetics
  • RNA, Untranslated / metabolism*
  • Urinary Bladder Neoplasms / genetics
  • Urinary Bladder Neoplasms / metabolism*
  • Urinary Bladder Neoplasms / pathology*

Substances

  • RNA, Long Noncoding
  • RNA, Untranslated
  • UCA1 RNA, human