Abstract
Colletoic acid, a novel 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor, was found and isolated from the cultured broth of the producing fungus Colletotrichum gloeosporioides SANK 21404. Its structure was determined to be a novel acorene-type sesquiterpene by several spectroscopic methods. The absolute structure of colletoic acid was established using a modified Mosher's method and single-crystal X-ray diffraction analysis.
MeSH terms
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11-beta-Hydroxysteroid Dehydrogenase Type 1 / antagonists & inhibitors*
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11-beta-Hydroxysteroid Dehydrogenase Type 2 / antagonists & inhibitors
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Chemical Phenomena
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Chemistry, Physical
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Colletotrichum / chemistry*
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Colletotrichum / classification
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Crystallography, X-Ray
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Cyclopentanes / chemistry
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Cyclopentanes / pharmacology*
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Dose-Response Relationship, Drug
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Enzyme Inhibitors / pharmacology*
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Esters / chemical synthesis
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Fermentation
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Humans
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Kinetics
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Magnetic Resonance Spectroscopy
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Models, Molecular
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Molecular Conformation
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Sesquiterpenes
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Spiro Compounds / chemistry
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Spiro Compounds / pharmacology*
Substances
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Cyclopentanes
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Enzyme Inhibitors
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Esters
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Sesquiterpenes
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Spiro Compounds
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colletoic acid
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11-beta-Hydroxysteroid Dehydrogenase Type 1
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11-beta-Hydroxysteroid Dehydrogenase Type 2