Ischemia-reperfusion treatment: opportunities point to modulation of the inflammatory response

Kidney Int. 2008 Jun;73(12):1333-5. doi: 10.1038/ki.2008.156.

Abstract

Ischemia-reperfusion injury is the leading cause of acute renal failure and determinant of renal-transplant outcome. Although many experimental studies show decreased injury and preserved renal function after dampening of the inflammatory response, surprisingly little progress has been made in the development of novel therapies.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chemokines / metabolism
  • Cytokines / metabolism
  • Graft Rejection / etiology
  • Graft Rejection / metabolism
  • Graft Rejection / prevention & control*
  • Humans
  • Kidney / blood supply*
  • Kidney / metabolism
  • Kidney Transplantation
  • Mice
  • Nephritis / etiology
  • Nephritis / metabolism
  • Nephritis / prevention & control*
  • Renal Insufficiency / etiology
  • Renal Insufficiency / metabolism
  • Renal Insufficiency / prevention & control*
  • Reperfusion Injury / complications
  • Reperfusion Injury / metabolism
  • Reperfusion Injury / therapy*

Substances

  • Chemokines
  • Cytokines