The methanolothermal reaction of (S)-1,4-diallyl-2-methylpiperazine (DAMP) with an excess CuBr affords a novel homochiral 3D framework (DAMP)3(Cu4Br4)2(H2O)3 (1) in which Cu4Br4 cubane acts as a connecting node to mimic the pure inorganic role in the ferroelectricity to enhance the remnant polarization value which is comparable to that of BaTiO3 synthesized by peptide-assisted synthesis.