Studies on the microsomal formation of arylating metabolites of acetaminophen and phenacetin

Mol Pharmacol. 1977 Jul;13(4):625-33.
No abstract available

MeSH terms

  • Acetaminophen / metabolism*
  • Animals
  • Cricetinae
  • Cytochrome P-450 Enzyme System / metabolism
  • Glutathione / metabolism
  • In Vitro Techniques
  • Kinetics
  • Male
  • Mass Spectrometry
  • Mesocricetus
  • Methylcholanthrene / pharmacology
  • Microsomes, Liver / enzymology
  • Microsomes, Liver / metabolism*
  • Mixed Function Oxygenases / metabolism
  • NADP / metabolism
  • Oxygen Isotopes
  • Phenacetin / metabolism*
  • Phenobarbital / pharmacology

Substances

  • Oxygen Isotopes
  • Acetaminophen
  • NADP
  • Methylcholanthrene
  • Cytochrome P-450 Enzyme System
  • Mixed Function Oxygenases
  • Phenacetin
  • Glutathione
  • Phenobarbital