Oxidation of alpha-methyldopa and other catechols by cytochrome P-450-generated superoxide anion: possible mechanism of methyldopa hepatitis

Mol Pharmacol. 1976 Nov;12(6):911-20.
No abstract available

MeSH terms

  • Animals
  • Catecholamines / metabolism*
  • Chemical and Drug Induced Liver Injury / etiology*
  • Cytochrome P-450 Enzyme System / metabolism*
  • Glutathione / metabolism
  • In Vitro Techniques
  • Kinetics
  • Male
  • Methyldopa / metabolism*
  • Methyldopa / pharmacology
  • Microsomes, Liver / metabolism
  • Oxidation-Reduction
  • Oxygen* / metabolism
  • Proteins / metabolism
  • Quinones / pharmacology
  • Rats
  • Superoxides* / metabolism

Substances

  • Catecholamines
  • Proteins
  • Quinones
  • Superoxides
  • Methyldopa
  • Cytochrome P-450 Enzyme System
  • Glutathione
  • Oxygen